| Rank |
Player |
Wins |
| 1 |
Cy Young |
511 |
| 2 |
Walter Johnson |
417 |
| 3 |
Christy Mathewson |
373 |
| 4 |
Pete Alexander |
373 |
| 5 |
Pud Galvin |
364 |
| 6 |
Warren Spahn |
363 |
| 7 |
Kid Nichols |
361 |
| 8 |
Tim Keefe |
342 |
| 9 |
Roger Clemens |
341 |
| 10 |
Steve Carlton |
329 |
| 11 |
John Clarkson |
328 |
| 12 |
Eddie Plank |
326 |
| 13 |
Don Sutton |
324 |
| 14 |
Nolan Ryan |
324 |
| 15 |
Phil Niekro |
318 |
| 16 |
Greg Maddux |
318 |
| 17 |
Gaylord Perry |
314 |
| 18 |
Tom Seaver |
311 |
| 19 |
Charles Radbourn |
309 |
| 20 |
Mickey Welch |
307 |
| 21 |
Lefty Grove |
300 |
| 22 |
Early Wynn |
300 |
| 23 |
Bobby Mathews |
297 |
| 24 |
Tommy John |
288 |
| 25 |
Bert Blyleven |
287 |
| 26 |
Robin Roberts |
286 |
| 27 |
Fergie Jenkins |
284 |
| 28 |
Tony Mullane |
284 |
| 29 |
Jim Kaat |
283 |
| 30 |
Tom Glavine |
275 |
| 31 |
Red Ruffing |
273 |
| 32 |
Burleigh Grimes |
270 |
| 33 |
Jim Palmer |
268 |
| 34 |
Bob Feller |
266 |
| 35 |
Eppa Rixey |
266 |
| 36 |
Jim McCormick |
265 |
| 37 |
Gus Weyhing |
264 |
| 38 |
Randy Johnson |
263 |
| 39 |
Ted Lyons |
260 |
| 40 |
Red Faber |
254 |
| 41 |
Jack Morris |
254 |
| 42 |
Carl Hubbell |
253 |
| 43 |
Al Spalding |
253 |
| 44 |
Bob Gibson |
251 |
| 45 |
Vic Willis |
249 |
| 46 |
Jack Quinn |
247 |
| 47 |
Joe McGinnity |
246 |
| 48 |
Jack Powell |
245 |
| 49 |
Amos Rusie |
245 |
| 50 |
Dennis Martinez |
245 |
|
